The imaging protocol consisted of pre-contrast T1 weighted imaging and bilateral dynamic contrast-enhanced imaging. The MRI study was performed using a 1.5 T MR scanner with a phase-array bilateral breast coil (Philips Medical Systems, Cleveland, Ohio). The pathological evidence of focal FCC of the breast was obtained by core needle biopsy under ultrasonography guidance in 8 patients and by operation specimen after mastectomy in 3 patients. Five patients had contralateral breast cancer, including 4 pure invasive ductal carcinomas and 1 invasive ductal carcinoma mixed with lobular component. All participants gave written informed consent. The breast MRI study was approved by the Institutional Review Board and was HIPAA compliant. Suspicious focal lesions were identified in either imaging modality. Prior to the breast MRI, all patients had mammography and 10 patients had received sonographic examination of the breast. These patients came to our institute due to suspicion of breast tumors by other imaging modalities. 2006, 11 patients (39–74 years old, mean 53) of pathology-proven focal FCC were identified from a breast MRI database of over 600 patients in our institution and retrospectively studied. The purpose of this study is to analyze the MR imaging features of focal FCC of the breast. MR imaging with regard to focal FCC has not been reported at all. Using mammography and sonography, although the imaging appearances of some subtypes of FCC have been reported ( 3– 5), MR imaging of FCC has been reported rarely ( 6). The existence of FCC sometimes also makes it difficult to detect cancer.įCC might appear occasionally as a focal discrete lesion mimicking a tumor in clinical and radiographic appearance. Although FCC is a benign condition, it may be misdiagnosed as a malignant lesion by physical examination or imaging studies. The response of the breast tissue to the monthly changes of estrogen and progesterone levels is believed to account for the pathogenesis of FCC. FCC includes a wide variety of histology, including stromal fibrosis, cysts, adenosis, apocrine metaplasia, and epithelial proliferation of various degrees ( 2). In conclusion, MR imaging features of focal FCC usually present as a mass or focus lesion with rapid enhancement and washout kinetics, which mimic a malignant breast lesion and lead to unnecessary operation, especially in patients with contra-lateral malignant breast cancer.įibrocystic change (FCC) is a commonly encountered condition of the breast that affects more than half of women ( 1). In pathology, all 11 patients showed the typical pathological features of fibrocystic change, with mixed components of stromal fibrosis, cyst formation, apocrine metaplasia, adenosis, and/or focal sclerosing adenosis. No statistically significant difference was found in the three diagnostic methods. Breast sonography suspected malignancy in 7 patients (7/10, 70%). Using mammography, 6 of the 11 patients (55%) were diagnosed as malignancy. Overall, 9 patients (82%) were suspected for malignancy using either criterion. Using kinetic enhancement curve, 8 of 13 lesions were suspected to be malignant. Morphologically, 3 patients were suspected as malignancy. The lesion size ranged from 4mm to 12mm (mean 6.7mm). Of the 11 patients, 7 were mass (≥5mm), 2 showed multiple foci, and 2 were focus (< 5mm). Eleven patients of pathology-proven focal FCC were retrospectively studied. This study aimed to analyze its MR imaging features. Imaging presentations of focal FCC are not well known. Focal fibrocystic change (FCC) of the breast is a rare form of FCC.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |